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Haemodynamic effects of a milrinone infusion without a bolus in patients undergoing off‐pump coronary artery bypass graft surgery
Author(s) -
Kwak Y. L.,
Oh Y. J.,
Shinn H. K.,
Yoo K. J.,
Kim S. H.,
Hong Y. W.
Publication year - 2004
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2004.03659.x
Subject(s) - medicine , milrinone , anesthesia , hemodynamics , bolus (digestion) , off pump coronary artery bypass , artery , anastomosis , cardiac output , coronary artery bypass surgery , cardiology , surgery , bypass grafting
Summary The haemodynamic effects of a continuous infusion of milrinone without an initial bolus dose were evaluated in patients undergoing off‐pump coronary artery bypass graft surgery. After internal mammary artery harvest, milrinone 0.5 μg.min −1 .kg −1 (29 patients) or a normal saline infusion (33 patients) was started and continued until all graft anastomoses were completed. Haemodynamic variables were recorded before application of the tissue stabiliser, at 1, 3, 5 and 10 min after the application of the stabiliser, and after its removal. The administration of a milrinone infusion was associated with a smaller decrease in cardiac output and mixed venous oxygen saturation during all the coronary artery anastomoses, with no severe complications and a decreased dose of norepinephrine infused to maintain systemic arterial pressure.