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Synacthen Depot® for the treatment of postdural puncture headache *
Author(s) -
Rucklidge M. W. M.,
Yentis S. M.,
Paech M. J.
Publication year - 2004
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2004.03573.x
Subject(s) - medicine , anesthesia , visual analogue scale , saline , randomized controlled trial , depot , prospective cohort study , significant difference , surgery , archaeology , history
Summary We conducted a prospective, randomised, double‐blind trial to study the effect of Synacthen Depot® in 18 parturients with postdural puncture headache following deliberate or accidental dural puncture. Women were randomly allocated to receive either Synacthen Depot 1 mg (1 ml) or 0.9% saline 1 ml intramuscularly. Using a 10‐cm visual analogue scale, severity of headache was measured before and at intervals until 48 h after injection. There was no difference in the severity of headache or requirement for epidural blood patch. We conclude that there is no advantage to the use of Synacthen Depot 1 mg for the treatment of postdural puncture headache.