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Assessment of tracheal intubation in children after induction with propofol and different doses of remifentanil
Author(s) -
Blair J. M.,
Hill D. A.,
Wilson C. M.,
Fee J. P. H.
Publication year - 2004
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2004.03524.x
Subject(s) - remifentanil , medicine , anesthesia , propofol , tracheal intubation , intubation , hemodynamics , heart rate , blood pressure , respiration , anatomy
Summary Tracheal intubating conditions were assessed in 112 children after induction of anaesthesia with propofol and remifentanil 1.0, 2.0 or 3.0 µg.kg −1 . Subjects in a control group were given propofol and mivacurium 0.2 mg.kg −1 . Haemodynamic and respiratory parameters were recorded. Plasma catecholamine levels were measured in a subgroup of 40 children. Intubating conditions were acceptable in 14/28 (50%), 18/26 (69%) and 22/27 (82%) in those subjects given remifentanil 1.0, 2.0 or 3.0 µg.kg −1 , respectively, and in 27/28 (96%) of the control group. Intubating conditions in subjects given remifentanil 3.0 µg.kg −1 were better than in those given remifentanil 1.0 µg.kg −1 ( p < 0.05). There were no significant differences in intubating conditions between those given remifentanil 3.0 µg.kg −1 and the control group. Systolic blood pressure and heart rate increased in response to tracheal intubation in subjects given remifentanil 1.0 µg.kg −1 and in the control group ( p < 0.05). Time to resumption of spontaneous respiration was prolonged in subjects given remifentanil 3.0 µg.kg −1 ( p < 0.001). In conclusion, remifentanil 2 µg.kg −1 provides acceptable intubating conditions and haemodynamic stability without prolonging the return of spontaneous respiration.