Premium
A randomised, controlled study of peri‐operative low dose s(+)‐ketamine in combination with postoperative patient‐controlled s(+)‐ketamine and morphine after radical prostatectomy *
Author(s) -
Snijdelaar D. G.,
Cornelisse H. B.,
Schmid R. L.,
Katz J.
Publication year - 2004
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2003.03620.x
Subject(s) - medicine , morphine , ketamine , anesthesia , bolus (digestion) , saline , analgesic , prostatectomy , adverse effect , surgery , prostate , cancer
Summary In a randomised, double‐blind prospective study we compared the effects on postoperative pain and analgesic consumption of intra‐operative s(+)‐ketamine (100 μg.kg −1 bolus and a continuous infusion of 2 μg.kg −1 .min −1 ) followed by postoperative patient‐controlled analgesia with morphine (1 mg per bolus) plus s(+)‐ketamine (0.5 mg per bolus), or intra‐operative saline followed by postoperative patient‐controlled analgesia morphine (1 mg per bolus) alone. A total of 28 male patients undergoing radical prostatectomy were studied. Morphine consumption, pain scores, pressure algometry and adverse effects were recorded for 48 h after surgery. Cumulative morphine consumption was significantly lower in the ketamine/morphine group (47.9 ± 26.2 mg) than in the saline/morphine group (73.4 ± 34.8 mg; p = 0.049). Pain scores at rest were significantly lower in the ketamine/morphine group across the 48‐h study period (p = 0.01). No significant differences were found in pressure algometry measurements or the occurrence of adverse effects.