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Cerebral and regional organ perfusion in pigs during xenon anaesthesia
Author(s) -
Schmidt M.,
Marx T.,
Kotzerke J.,
Lüderwald S.,
Armbruster S.,
Topalidis P.,
Schirmer U.,
Reinelt H.
Publication year - 2001
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.2001.02322.x
Subject(s) - medicine , brainstem , perfusion , medulla oblongata , cerebral perfusion pressure , anesthesia , cerebral cortex , cerebellum , cortex (anatomy) , cerebral blood flow , central nervous system , cardiology , neuroscience , biology
Little is known about the haemodynamic effects of inhaled xenon on regional organ perfusion. The aim of this study was to investigate the effect of 79% xenon ventilation on organ perfusion in pigs. We investigated 10 pigs, which were randomly allocated to receive either xenon 79% or total intravenous anaesthesia (TIVA)/oxygen anaesthesia. Microspheres were used to determine organ perfusion. The following regions of interest were investigated: cerebral cortex, medulla oblongata, brainstem, cerebellum, liver, kidney, small intestine, colon, muscle, skin and heart. The results demonstrated a significant increase in regional perfusion in the brainstem (+63%), cerebral cortex (+38%), medulla oblongata (+35%) and cerebellum (+34%). All other organs showed no significant change in regional perfusion. We conclude that xenon should be used with caution in clinical situations associated with pathological increases in intracranial pressure, e.g. neurosurgical procedures, head injury, cerebral mass lesions or stroke.