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Serum glutathione S‐transferase concentrations and creatinine clearance after sevoflurane anaesthesia
Author(s) -
Darling J. R.,
Murray J. M.,
McBride D. R.,
Trinick T. R.,
Fee J. P. H.
Publication year - 1997
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1997.26-az025.x
Subject(s) - sevoflurane , medicine , isoflurane , normocapnia , creatinine , renal function , anesthesia , nitrous oxide , glutathione , biochemistry , chemistry , acidosis , hypercapnia , enzyme
The effects of sevoflurane and isoflurane on serum glutathione S‐transferase concentrations and creatinine clearance were compared in 50 ASA I–III patients aged over 18 years undergoing body surface surgery of 1–3 h predicted duration. Patients randomly received sevoflurane ( n = 24) or isoflurane ( n = 26) in nitrous oxide and oxygen ( F IO 2 = 0.4) via a nonrebreathing system. Fluids were standardised and patient’s lungs ventilated to normocapnia. Expired concentration of anaesthetic agent was adjusted to maintain systolic arterial pressure between 70 and 100% of baseline. Patients received significantly less (p < 0.05) sevoflurane (1.0 MAC‐h) than isoflurane (1.5 MAC‐h). Using serum glutathione S‐transferase concentrations and creatinine clearance as markers of hepatic and renal function respectively, no statistically significant differences were identified between the groups.