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The effect of co‐induction with midazolam upon recovery from propofol infusion anaesthesia
Author(s) -
Tighe K. E.,
Warner J. A.
Publication year - 1997
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1997.198-az0333.x
Subject(s) - midazolam , propofol , medicine , anesthesia , alfentanil , saline , placebo , sedation , alternative medicine , pathology
Forty‐eight patients undergoing day‐case anaesthesia were asked to complete pre‐ and postoperative tests of psychomotor function in order to study the influence of co‐induction with midazolam in conjunction with propofol/alfentanil anaesthesia on postoperative psychomotor recovery. The study was placebo controlled and double blind with patients receiving either 0.03 mgkg −1 of midazolam or saline 2 min before induction of anaesthesia with propofol and alfentanil. Patients who underwent co‐induction with midazolam had significantly impaired concentration and rapidity of response but improved accuracy and vigilance when compared with those who received saline. The study confirmed that co‐induction with a subanaesthetic dose of midazolam reduced the induction dose of propofol by up to 50%. We conclude that co‐induction with midazolam reduces psychomotor recovery in the immediate postoperative phase following propofol infusion anaesthesia.