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Fatal hepatic necrosis after isoflurane anaesthesia
Author(s) -
Weitz J.,
Kienle P.,
Böhrer H.,
Hofmann W.,
Theilmann L.,
Otto G.
Publication year - 1997
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1997.187-az0319.x
Subject(s) - medicine , isoflurane , fulminant hepatic failure , enflurane , fulminant , anesthesia , necrosis , surgery , liver transplantation , transplantation
Several halogenated anaesthetic agents have been associated with hepatotoxicity. We report a case of fulminant, fatal hepatic necrosis after uneventful isoflurane anaesthesia in a patient without previous liver disease, who may have been sensitised by previous exposure to enflurane. Although no anti‐trifluoroacetyl antibodies could be detected in the patient's serum, isoflurane hepatotoxicity seems very likely to be the reason for fulminant hepatic failure in this patient.