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Effects of a single pre‐operative dexmedetomidine dose on isoflurane requirements and peri‐operative haemodynamic stability
Author(s) -
Lawrence C. J.,
De Lange S.
Publication year - 1997
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1997.169-az0303.x
Subject(s) - dexmedetomidine , medicine , isoflurane , perioperative , anesthesia , hemodynamics , medetomidine , sedation , blood pressure , heart rate
In a double‐blind, placebo‐controlled study we investigated the effect of a single pre‐induction intravenous dose of dexmedetomidine 2 μg.kg −1 on anaesthetic requirements and peri‐operative haemodynamic stability in 50 patients undergoing minor orthopaedic and general surgery. Patients were anaesthetised with nitrous oxide/oxygen/fentanyl, supplemented if necessary with isoflurane. The mean (SD) intra‐operative isoflurane concentration was lower in the dexmedetomidine‐treated patients than controls (0.01 (0.03)% compared to 0.1 (0.1)%; p = 0.001) although six of the 25 treated patients required isoflurane at some stage. The haemodynamic response to tracheal intubation and extubation was reduced in the dexmedetomidine group as was intra‐operative heart rate variability; postoperative analgesic and anti‐emetic requirements and peri‐operative serum catecholamine concentrations were lower in the dexmedetomidine group. Hypotension and bradycardia occurred more frequently after dexmedetomidine.