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Prediction of infusion rates of rocuronium using the bolus test dose technique
Author(s) -
Harrison M. J.
Publication year - 1997
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1997.001-az004.x
Subject(s) - rocuronium , medicine , bolus (digestion) , anesthesia , rocuronium bromide , continuous infusion , surgery , intubation
Twenty‐four patients were given a loading dose of rocuronium 1.0 mg.kg −1 intravenously followed by boluses of 20 mg ( n = 19) and 10 mg ( n = 24) after return of T1 of the train‐of‐four to 5% of control. Neuromuscular function was assessed using a Relaxograph. The time was recorded for the return of T1 to 5% after the administration of the boluses and subsequently an infusion of rocuronium was started. The aim was to maintain T1 between 3% and 7% of control for at least 40 min without a change of infusion rate. The correlations between the duration of the test doses and the infusion rates were −0.94 (10 mg) and −0.86 (20 mg). The predictive accuracy of the 10 mg bolus was assessed in a further 10 patients. At the termination of the infusion three patients had a T1% that was outside the desired range of 3–7%. A 10 mg bolus that lasts 6 min indicates a need for an infusion of at least 60 mg.h −1 , 8 min (50 mg.h −1 ), 10 min (40 mg.h −1 ), 15 min (30 mg.h −1 ), 24 min (20 mg.h −1 ) and 34 min (15 mg.h −1 ).