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Serum and urinary myoglobin following an aborted malignant hyperthermia reaction
Author(s) -
Laurence A. S.,
Vanner G. K.,
Collins W.,
Hopkins P. M.
Publication year - 1996
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1996.tb14965.x
Subject(s) - medicine , myoglobin , creatine kinase , malignant hyperthermia , hyperthermia , anesthesia , urinary system , perfusion , myoglobinuria , creatinine , rhabdomyolysis , surgery , cardiology , biochemistry , chemistry
Summary A 13‐year‐old boy presenting for correction of bat ears was anaesthetised with thiopentone and suxamethonium, the administration of which was followed by jaw spasm, poor peripheral perfusion (without cyanosis) and marked tachycardia. The procedure was abandoned, dantrolene and Ringer lactate IL were given intravenously and the patient regained consciousness I h later. Levels of serum myoglobin, urinary myoglobin and creatine kinase were followed until they returned to normal. Despite a peak serum myoglobin of 58 000 μg.l −1 and peak urinary level of 446 000 μg.1 −1 , no renal impairment occurred. Subsequent testing for susceptibility to malignant hyperthermia proved positive for the patient and four other members of the family.