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The effect of increasing the dose of buprenorphine on the haemodynamic response associated with tracheal intubation
Author(s) -
Khan F. A.,
Kamal R. S.
Publication year - 1996
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1996.tb13646.x
Subject(s) - buprenorphine , medicine , anesthesia , heart rate , intubation , haemodynamic response , hemodynamics , tracheal intubation , blood pressure , placebo , saline , mean arterial pressure , opioid , receptor , alternative medicine , pathology
Summary The effect of buprenorphine on the haemodynamic response to tracheal intubation was studied at two dose levels, 2.5 μg.kg ‐1 and 5 μg.kg ‐1 , in a placebo‐controlled double‐blind trial in 75 patients undergoing laparoscopic cholecystectoniy. The study drugs were administered intravenously 8 min before induction of anaesthesia with thiopentone 5 mg.kg ‐1 and vecuronium 0.1 mg/kg ‐1 . Buprenorphine 2.5 μg.kg ‐1 caused 50% attenuation of the blood pressure response whereas 5 μg.kg ‐1 caused 70% attenuation compared to the saline placebo. The maximum increase in heart rate was 14% of the control value after 2.5 μg.kg ‐1 and 11% after 5 μg.kg ‐1 of buprenorphine. A significant difference in heart rate was also observed between the two buprenorphine groups at 5 and 10 min after intubation. Blood pressure and heart rate both showed a significant fall from baseline values 10 min after intubation in both buprenorphine groups, with the changes being greater in the 5 μg.kg ‐1 group. We recommend the use of 2.5 μg.kg ‐1 buprenorphine for attenuation of the hypertensive response to intubation in major abdominal surgery.