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Tropisetron and metoclopramide in the prevention of postoperative nausea and vomiting
Author(s) -
ALIMELKKILÄ T.,
KANTO J.,
KATEVUO R.
Publication year - 1996
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1996.tb13639.x
Subject(s) - tropisetron , metoclopramide , medicine , nausea , vomiting , anesthesia , postoperative nausea and vomiting , placebo , antiemetic , receptor , alternative medicine , pathology , antagonist
Summary One hundred and twenty patients undergoing elective ophthalmic surgery under general anaesthesia were investigated in a randomised, double‐blind, parallel group study of postoperative nausea and vomiting. Patients received tropisetron 0.1 mg.kg –1 , metoclopramide 0.25mg.kg –1 or placebo given at the end of anaesthesia. In comparison with placebo, tropisetron significantly reduced the degree of nausea (p< 0.01), whereas metoclopramide reduced both nausea (p < 0.05) and vomiting (p < 0.05). There were no statistically significant differences between the two active agents in their efficacy to postoperative nausea and vomiting. The patients in the placebo group required rescue antiemesis more often in the postanaesthesia care unit. Our results suggest that tropisetron may not be suitable as a routine, primary therapy for the prevention of postoperative nausea and vomiting.