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Osteogenesis imperfecta and malignant hyperthermia
Author(s) -
Porsborg P.,
Astrup G.,
Bendixen D.,
Lund A. M.,
Ørding H.
Publication year - 1996
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1996.tb12619.x
Subject(s) - malignant hyperthermia , medicine , hypermetabolism , osteogenesis imperfecta , hyperthermia , anesthesia , contracture , metabolic acidosis , fentanyl , dantrolene , respiratory acidosis , acidosis , tachycardia , surgery , pathology , calcium
Summary We describe a patient with osteogenesis imperfecta who developed tachycardia, metabolic and respiratory acidosis (pH 7.14, Pco 2 8.4 kPa, BE 8.5 mmol.l ‐1 ) and hyperthermia up to 40°C during anaesthesia with barbiturates, fentanyl, pancuronium, and nitrous oxide. Malignant hyperthermia was suspected and the patient treated accordingly. Two years later the in‐vitro contracture test for malignant hyperthermia was completely normal. We conclude that hypermetabolism in patients with osteogenesis imperfecta is due to unknown mechanisms other than malignant hyperthermia .