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Plasma concentrations of bupivacaine following single needle lumbar sympathectomy using two volumes of 0.25% bupivacaine plain solution
Author(s) -
DICK A. M.,
GABBOTT D. A.,
HARDY P. A. J.
Publication year - 1996
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1996.tb07889.x
Subject(s) - bupivacaine , medicine , lumbar sympathectomy , anesthesia , lumbar , plasma concentration , volume (thermodynamics) , sympathectomy , surgery , physics , quantum mechanics
Summary Plasma buipvacaine concentrations were measured in 10 patients after lumbar sympathectomy using 10ml or 20ml of 0.25% bupivacaine plain solution. A single needle technique was employed, positioned at the L 3 level. Mean peak concentrations were greater in the larger volume group and were statistically significant at 20, 30, 60, 90 and 120 min. Plasma bupivacaine levels peaked earlier in the smaller volume group. Some patients in the larger volume group still had plasma bupivacaine levels at or near peak values at 120 min. No patient approached toxic plasma levels of bupivacaine.