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Effect of bupivacaine‐induced spinal block on the hypnotic requirement of propofol
Author(s) -
TVERSKOY M.,
FLEYSHMAN G.,
BACHRAK L.,
BENSHLOMO I.
Publication year - 1996
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1996.tb07847.x
Subject(s) - medicine , propofol , bupivacaine , anesthesia , hypnotic , ed50 , spinal anesthesia , potency , block (permutation group theory) , biochemistry , chemistry , receptor , geometry , mathematics , in vitro
Summary The hypnotic dose‐response of propofol was compared with its combination with either bupivacaine‐induced spinal block or intramuscular bupivacaine 12.5mg in 105 men, divided into three groups of 35, undergoing lower abdominal, pelvic or lower limb surgery. Dose‐response curves were determined for each group using bootstrap analysis. Bupivacaine‐induced spinal block at the level of T 8 ‐T 9 was found to reduce the ED 50 , of propofol by 39%. While this enhancement of hypnotic effect by spinal block is mostly attributable to reduced afferent input, differences in its potency between drugs suggest a role for additional factors.