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Spinal anaesthesia induced by intrathecal magnesium sulphate An experimental study in a rat model
Author(s) -
BAHAR M.,
CHANIMOV M.,
GRINSPUN E.,
KOIFMAN I.,
COHEN M. L.
Publication year - 1996
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1996.tb07843.x
Subject(s) - medicine , anesthesia , intrathecal , spinal anesthesia , magnesium , bolus (digestion) , sedation , neurotoxicity , intravenous bolus , hemodynamics , surgery , toxicity , materials science , metallurgy
Summary We have demonstrated in a rat model that the intrathecal injection of 0.02 ml of 6.3% magnesium sulphate, a concentration iso‐osmolar with rat plasma, will produce a state of spinal anaesthesia and general sedation, lasting approximately 1 h. These effects reversed completely after 6 h, without evidence of neurotoxicity, immediately or during the period 1 week following the injection. The accompanying changes in haemodynamic and respiratory functions were minimal throughout the period of anaesthesia and compare favourably with those induced by an intrathecal bolus of 0.04 ml of 2% lignocaine.