Premium
Antiemetic efficacy of prophylactic ondansetron in laparoscopic cholecystectomy
Author(s) -
KOIVURANTA M. K.,
And E. LÄÄRÄ,
RYHÄNEN P. T.
Publication year - 1996
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1996.tb07654.x
Subject(s) - ondansetron , medicine , antiemetic , nausea , anesthesia , vomiting , placebo , postoperative nausea and vomiting , laparoscopic cholecystectomy , adverse effect , cholecystectomy , surgery , alternative medicine , pathology
Summary The antiemetic efficacy of ondansetron given prophylactically was investigated in a randomised, double‐blind, placebo‐controlled trial of 63 patients undergoing laparoscopic cholecystectomy. The patients received intravenously prior to anaesthesia either ondansetron 4 mg or placebo. The same standardised general anaesthetic technique was used. Nausea, emetic episodes and the need for rescue medication were recorded for 24 h postoperatively. Nausea was experienced by 64% of the patients in the ondansetron group and 56% in the placebo group, and emetic episodes occurred in 45% and 50% of the patients in the two groups, respectively. The proportions of patients given rescue antiemetic medication were 45% and 44%, respectively. No clinically important adverse events were observed. In conclusion, ondansetron given prior to anaesthesia in a dosage of 4mg did not prevent postoperative nausea and vomiting after laparoscopic cholecystectomy.