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The relationship between anaesthetic uptake and cardiac output
Author(s) -
WATT S. J.,
COOK L. B.,
OHRI S.,
LOCKWOOD G. G.
Publication year - 1996
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1996.tb07648.x
Subject(s) - medicine , enflurane , anesthesia , cardiac output , expired air , pulmonary artery catheter , cardiac surgery , ventilation (architecture) , catheter , controlled ventilation , fick principle , cardiology , halothane , surgery , hemodynamics , mechanical engineering , engineering
Summary The hypothesis that anaesthetic uptake during maintenance of anaesthesia is related to cardiac output was tested on 21 patients undergoing cardiac surgery. Using a computer‐controlled closed breathing system, enflurane was administered to maintain an end‐expired concentration of 1%. Cardiac output was measured by thermodilution using a pulmonary artery catheter. A clear qualitative but not quantitative relationship was demonstrated. Changes in anaesthetic requirements at a constant end‐expired concentration are a better guide to changes in cardiac output than changes in end‐expired carbon dioxide with constant ventilation in patients undergoing cardiac surgery .