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The effects of thiopentone and propofol on delayed hypersensitivity reactions
Author(s) -
DEVLIN E. G.,
CLARKE R. S. J.,
MIRAKHUR R. K.,
McNEILL T. A.
Publication year - 1995
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1995.tb06037.x
Subject(s) - medicine , propofol , anesthesia , delayed hypersensitivity , immunology , immune system
Summary The effects of thiopentone and propofol on delayed hypersensitivity reactions and T lymphocyte proliferation were studied in nine healthy volunteers (five women and four men). Thiopentone 5 mg.kg ‐1 and propofol 2.5mg kg ‐1 were given as a 10 min infusion on two separate occasions. The volunteers were exposed to a skin multitest antigen before and after administration of the two agents and their skin reactions assessed. T lymphocyte responses were studied using phytohaemagglutinin (PHA)‐induced proliferation. Results showed that both drugs caused a significant depression of skin reactions in vivo but no depression in the T lymphocyte proliferation.