Premium
Time course of action and intubating conditions following vecuronium, rocuronium and mivacurium
Author(s) -
WIERDA J. M. K. H.,
HOMMES F. D. M.,
NAP H. J. A.,
BROEK L.
Publication year - 1995
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1995.tb05990.x
Subject(s) - rocuronium , medicine , anesthesia , fentanyl , tracheal intubation , rocuronium bromide , muscle relaxant , onset of action , intubation , isoflurane , vecuronium bromide
Summary The purpose of this study was to compare the time course of action and tracheal intubating conditions of vecuronium, rocuronium and mivacurium in anaesthetised patients. Anaesthesia consisted of thiopentone, fentanyl, N 2 O/O 2 and isoflurane. After a 2 × ED 90 dose the first attempt at tracheal intubation was made at 90s. If required, maintenance doses of 0.5 × ED 90 were administered. The intubating conditions after rocuronium were significantly better than those after vecuronium and mivacurium. The average onset times of rocuronium (172 s) and vecuronium (192 s) were significantly shorter than that of mivacurium (229 s). The clinical duration and recovery time were significantly shorter after mivacurium (13 and 6min, respectively) than with vecuronium (33 and 14min, respectivelys) and rocuronium (28 and 11 min, respectively). We conclude that rocuronium might be of advantage whenever the interval between the administration of the muscle relaxant and tracheal intubation must be short, whereas mivacurium may be of benefit if fast spontaneous recovery is required.