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Cardiovascular and catecholamine response to surgery in brain‐dead organ donors
Author(s) -
FITZGERALD R. D.,
DECHTYAR I.,
TEMPL E.,
FRIDRICH P.,
LACKNER F. X.
Publication year - 1995
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1995.tb05989.x
Subject(s) - medicine , catecholamine , anesthesia , hemodynamics , blood pressure , heart rate , surgery , epinephrine , surgical stress , plasma levels
Summary Eleven brain‐dead organ donors were studied during surgery. Plasma levels of adrenaline and noradrenaline were measured before and after skin incision, upon sternotomy and 15, 30 and 45min thereafter. Haemodynamic changes were measured continuously throughout the observation period. Blood pressure and heart rate increased after skin incision, remained high at sternotomy then decreased towards the end of the observation period in six of the 11 patients. Plasma catecholamines increased promptly with the onset of surgical stimuli. We conclude that surgical stress can evoke an excessive rise of plasma adrenaline and noradrenaline and thus could impair allograft function.