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Postoperative analgesia with transdermal fentanyl following lower abdominal surgery
Author(s) -
BROOME I. J.,
WRIGHT B. M.,
BOWER S.,
REILLY C. S.
Publication year - 1995
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1995.tb04603.x
Subject(s) - medicine , transdermal , fentanyl , anesthesia , placebo , sedation , abdominal surgery , morphine , transdermal patch , surgery , pharmacology , alternative medicine , pathology
Summary In a randomised, placebo‐controlled, double‐blind study involving 81 patients undergoing total abdominal hysterectomy, the postoperative analgesia provided by transdermal fentanyl given at 25, 50, or 75μg.h ‐1 for 72h was compared with a placebo group. The efficacy of the Transdermal Therapeutic System was related to the rate of fentanyl delivery, higher rates being associated with significantly lower visual analogue pain scores (24, 20, 17 and 13, for placebo, 25, 50 and 75μg.h ‐1 respectively) and reduced patient controlled analgesia morphine requirements (44, 38, 33 and 31 mg respectively). Patients’overall sedation scores were not increased by transdermal fentanyl, but respiratory rates decreased with higher transdermal fentanyl dosage.