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The effect of midazolam premedication on implicit memory activation during alfentanil‐nitrous oxide anaesthesia
Author(s) -
ROODE A.,
JELICIC M.,
BONKE B.,
BOVILL J. G.
Publication year - 1995
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1995.tb04553.x
Subject(s) - premedication , alfentanil , anesthesia , midazolam , medicine , nitrous oxide , general anaesthesia , sedation , propofol
Summary Eighty‐three patients were given midazolam 0.1 mg.kg ‐1 by intramuscular injection as premedication before general anaesthesia with alfentanil‐nitrous oxide. During anaesthesia patients were presented (through headphones) with either statements about common facts of some years ago (group A) (n = 43) or new verbal associations, e.g. names of fictitious, nonfamous people (group B) (n = 40). In a previous study with the same anaesthetic technique, but without premedication there was significant activation of implicit memory (p < 0.001). In this study we found no explicit or implicit memory for the auditory information presented during anaesthesia. Midazolam premedication can prevent implicit memory activation during alfentanil‐nitrous oxide anaesthesia.