Premium
The effect of parenteral diclofenac and morphine on duration and height of blockade of continuous epidural infusion of bupivacaine 0.5%
Author(s) -
SCOTT N. B.,
FORBES D. W.,
BINNING A. R.
Publication year - 1994
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1994.tb14227.x
Subject(s) - medicine , bupivacaine , anesthesia , diclofenac , blockade , morphine , saline , epidural block , continuous infusion , surgery , receptor
Summary Twenty‐six patients undergoing abdominal hysterectomy (ASA 1‐2) were entered into a double‐blind randomised trail to determin: (a) whether diclofanac given intravenously could influence the effective duration of a continuous epidural infusion of bupivacine 0.5% and (b)0 whether morphine given intravenously altered the height of the regressing block. A block to T 4 was established pre‐operatively and a continuous infusion of 0.5% bupivacaine 8 ml.h −1 ran for 14 h. Thirteen patients received 50 mg diclofenac intramuscularly before surgery repeated at 4 and 10h later and 13 patients received saline intramuscularly. the height of blockade and pain scores were measured hourly. Effectibe block duration was defined as regression to t 10 or lower andlor a pain a score of 2 or more,. At this point 10 mg of morphine was given intravenously and the height of the block reassessed. Duration of blockade was not significantly prolonged (p>.05), but pain scores were significantly reduced with diclofenac (p<.01). Morphine did not alter blockade height. It is concluded that epidural bupivacaine and diclogenac act additively on postoperative pain.