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Oral administration of midazolam as a premedicant for paediatric day‐case anaesthesia
Author(s) -
McCLUSKEY A.,
MEAKIN G. H.
Publication year - 1994
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1994.tb04451.x
Subject(s) - midazolam , medicine , anesthesia , placebo , general anaesthesia , sedation , alternative medicine , pathology
Summary Fifty‐four children aged 1–10 years, scheduled for day‐case anaesthesia were prescribed either oral midazolam 0.5 mg.kg ‐1 or a placebo preparation 30‐60 min pre‐operatively on a double‐blind basis. On arrival at the induction room, anxiolysis was satisfactory in 23 out of 24 (96%) children who received midazolam compared with 12 out of 27 (44%) of those who received placebo (p < 0.001); at induction of anaesthesia these proportions were 21 out of 24 (88%) and nine out of 27 (33%) respectively (p < 0.001). The time to early recovery from anaesthesia was somewhat longer in children premedicated with midazolam compared with controls (28.2 vs 21.9 min) (p < 0.05). Similarly, the time to hospital discharge was longer in the midazolam group (244 vs 185 min) (p < 0.01). Analysis of behavioural questionnaires completed by parents 2 weeks after hospitalisation indicated that there were fewer postoperative behavioural disturbances in children premedicated with midazolam compared with controls (p < 0.05).