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A comparison of Plasmalyte 148 and 0.9% saline for intra‐operative fluid replacement
Author(s) -
McFARLANE C.,
LEE A.
Publication year - 1994
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1994.tb04450.x
Subject(s) - medicine , saline , acidosis , metabolic acidosis , sodium bicarbonate , bicarbonate , anesthesia , surgery , chemistry
Summary Thirty patients undergoing major hepatobiliary or pancreatic surgery were randomly allocated to receive either 0.9% saline or Plasmalyte 148 (a balanced salt solution), at 15 ml.kg ‐1 .h ‐1 . Arterial blood gas analysis was performed before and after surgery. Plasma biochemistry (Na + , K + , Cl ‐ , lactate) measurements were made before and after surgery and at 24 h after surgery. The patients receiving 0.9% saline had significantly increased chloride concentrations (p < 0.01), decreased standard bicarbonate concentrations (p < 0.01) and increased base deficit (p < 0.01) compared to those receiving Plasmalyte 148. There were no significant changes in plasma sodium or potassium or blood lactate concentrations in either group. The exclusive use of 0.9% saline intra‐operatively can produce a temporary hyperchloraemic acidosis which could be given false pathological significance. In addition it may exacerbate an acidosis resulting from an actual pathological stale. The use of a balanced salt solution such as Plasmalyte 148 may avoid these complications.