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Haemodynamic effects of R 80122 immediately after cardiopulmonary bypass; preliminary results
Author(s) -
Herregods L.,
Roily G.,
Belleghem Y.,
Nooten G.
Publication year - 1994
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1994.tb04409.x
Subject(s) - medicine , cardiopulmonary bypass , hemodynamics , vascular resistance , weaning , cardiac output , anesthesia , inotrope , vasodilation , blood pressure , coronary artery bypass surgery , cardiology , heart rate , artery
Summary R 80122 is a new short‐acting phosphodiesterase type III inhibitor. In a preliminary investigation, three patients, scheduled for coronary artery bypass surgery, were given R 80122 after weaning from cardiopulmonary bypass. Two patients received 10μig.kg ‐1 .min ‐1 for 10 min as a loading infusion followed by a 5 μg.kg ‐1 .min ‐l maintenance dose. One patient received a 20 μg.kg ‐1 .min‐1 for 10 min loading infusion followed by a 10 μg.kg ‐1 min‐1 maintenance infusion. After weaning from cardiopulmonary bypass and during the administration period, no arrhythmias or cardiac ischaemia were detected. The administration of R 80122 improved the haemodynamic profile with an increase in cardiac output, a decrease in systemic vascular resistance and a stable heart rate and mean arterial blood pressure. These preliminary results indicate that R 80122 possesses positive inotropic activity in combination with vasodilating properties.