Premium
Effect of ketorolac, ketoprofen and nefopam on platelet function
Author(s) -
DORDONI P. L.,
VENTURA M. DELLA,
STEFANELLI A.,
IANNACE E.,
PAPARELLA P.,
ROCCA B.,
ACCORRA F.
Publication year - 1994
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1994.tb04352.x
Subject(s) - ketorolac , ketoprofen , medicine , analgesic , anesthesia , bleeding time , platelet , hemostasis , pharmacology , antipyretic , surgery , platelet aggregation
Summary Ketorolac, ketoprofen and nefopam are often used in the treatment of postoperative pain. While nefopam is a non‐narcotic, non‐opioid central analgesic agent, ketorolac and ketoprofen are non‐steroidal anti‐inflammatory drugs, which, due to their prostaglandin‐synthetase inhibiting activity, have antiplatelet effects. In this study we investigated the effect of ketorolac, ketoprofen and nefopam on platelet function by performing bleeding time and in vitro platelet aggregation in 30 healthy volunteers (10 for each treatment) before and 3h after drug administration. Nefopam did not affect bleeding time and platelet aggregation, while ketorolac and ketoprofen significantly prolonged bleeding time without significantly inhibiting platelet aggregation in response to adenosine diphosphate. The prolongation of bleeding time observed after ketorolac and ketoprofen may have clinical relevance and suggests that nefopam could be more safely administered for the treatment of postoperative pain, especially in patients with haemostatic defects or after high bleeding risk surgery.