Premium
The effect of oral omeprazole on the disposition of lignocaine
Author(s) -
NOBLE D. W.,
BANNISTER J.,
LAMONT M.,
ANDERSSON T.,
SCOTT D. B.
Publication year - 1994
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1994.tb03519.x
Subject(s) - medicine , disposition , omeprazole , anesthesia , pharmacology , psychology , social psychology
Summary The effects of the gastric antisecretory drug, omeprazole, on the disposition of lignocaine were studied in 10 healthy male volunteers in a double‐blind, randomised, placebo‐controlled, two‐period crossover trial. Omeprazole 40 mg or placebo was taken daily for one week before administration of lignocaine 1 mg.kg ‐1 (3.7 μmol.kg ‐1 ) given intravenously over 10 min. Venous concentrations of lignocaine and its metabolite monoethylglycinexylidine were measured in plasma with reversed phase liquid chromatography. The mean (95% CI) areas under the curve at infinity for lignocaine after pretreatment with omeprazole or placebo were 6.67 (4.90–8.45) μmol.h.l ‐1 and 6.14 (5.05‐7.23) μmol.h.l ‐1 , respectively (p = 0.44). The respective areas for monoethylglycinexylidine were 1.85 (1.25‐2.45) μmol.h.l ‐1 and 1.79 (1.44‐2.14) μmol.h.r ‐1 (p = 0.78). Similarly, omeprazole had no significant effect on the half‐lives of lignocaine or methylglycinexylidine.