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Creatinine and 51 Cr‐EDTA clearance after liver transplantation
Author(s) -
BURNS A. M.,
HUE D. P.,
WRAIGHT E. P.,
PARK G. R.
Publication year - 1993
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1993.tb07585.x
Subject(s) - medicine , creatinine , liver transplantation , transplantation , urology , renal function , radiochemistry , chemistry
Summary We have compared glomerular filtration rate measured by creatinine clearance with that measured by 51 Cr‐EDTA clearance after liver transplantation. Fourteen pairs of values were obtained from seven patients on the first and second days after operation. There were wide discrepancies between the values for glomerular filtration rate measured by the two methods, with a regression co‐efficient of 0.43 (p = 0.12). Both methods assume a steady state, with no change of extracellular fluid volume or in the rates of exchange between physiological compartments, that does not apply in the immediate period after operation. The results show the difficulties of using clearance techniques to assess renal function after major surgery. Since drug therapy may be based on these measurements, we suggest that in this group of patients isolated clearance values should not be used.