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Comparison of 2‐chloroprocaine and prilocaine for intravenous regional anaesthesia of the arm: a clinical study
Author(s) -
Pitkänen M.,
Kyttä J.,
Rosenberg P. H.
Publication year - 1993
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1993.tb07536.x
Subject(s) - medicine , prilocaine , anesthesia , regional anaesthesia , local anesthetic
Summary In a double‐blind, randomised study of patients scheduled for minor hand surgery 0.5% 2‐chloroprocaine (n = 30) and 0.5% prilocaine (n = 30) in a volume of 40 ml were compared for intravenous regional anaesthesia. The onset of sensory and motor block and recovery of sensory block were determined, and the occurrence of side‐effects was noted. Twenty‐four patients in the 2‐chloroprocaine group and 17 in the prilocaine group developed complete sensory block by 15 min after injection (p < 0.05). Complete recovery of sensation was faster after prilocaine (7.1 min) than 2‐chloroprocaine (9.8 min) (p<0.01). Venous irritation and/or urticaria after tourniquet release was observed on 10 occasions in those receiving 2‐chloroprocaine and twice in those receiving prilocaine. An increase in heart rate of > 20% above control values occurred in three patients, all of whom had been given 2‐chloroprocaine. Clinically, local anaesthetic properties of 0.5% 2‐chloroprocaine and prilocaine were similar, but there were more side‐effects with the former drug.