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Resistance to vecuronium
Author(s) -
NORMAN J.
Publication year - 1993
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1993.tb07529.x
Subject(s) - medicine , neostigmine , neuromuscular transmission , vecuronium bromide , anesthesia , neuromuscular blockade , anticipation (artificial intelligence) , muscle relaxation , electromyography , physical medicine and rehabilitation , artificial intelligence , computer science
Summary A 19‐year‐old epileptic patient taking carbamazepine was anaesthetised for a sigmoid colectomy. Such patients are reported to show a resistance to the actions of competitive neuromuscular blocking drugs, and a conventional dose of vecuronium (0.1 mg.kg −1 ) produced relaxation for only 18 min. Subsequently she received vecuronium 6.7 mg.h' which kept the first twitch of the train‐of‐four response at 30% of the control value. Antagonism with neostigmine 1.25 mg produced a rapid and full recovery. The report illustrates the usefulness of monitoring neuromuscular transmission whenever there is an anticipation of an altered response.