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Plasma concentrations of lignocaine after thoracic paravertebral blockade in infants and children
Author(s) -
LÖNNQVIST P.A.
Publication year - 1993
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1993.tb07473.x
Subject(s) - medicine , anesthesia , bolus (digestion) , plasma concentration , lidocaine , blockade , local anesthetic , bupivacaine , intravenous bolus , surgery , receptor
Summary Plasma concentrations of lignocaine were determined in six ASA I children treated with thoracic paravertebral blockade. Peak concentrations ranged between 1.7 and 3.0 μg.ml −1 after a bolus injection of lignocaine 0.5 ml.kg −1 (lignocaine 10 mg.ml −1 with adrenaline 5 μg.ml −1 ) and peak plasma concentrations were reached 15–30 min after injection. Two hours after the initial bolus a continuous infusion of the same lignocaine solution was started (0.25 ml.kg −1 .h −1 ). Steady state levels of lignocaine were reached 8–10 h after the start of the infusion and ranged from 2.1–3.2 μg.ml −1 . This regimen for paravertebral block in children resulted in moderate plasma concentrations of lignocaine, well below those which might result in side effects or systemic toxicity.