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Sedation with propofol during surgery under local blockade
Author(s) -
SKIPSEY I. G.,
COLVIN J. R.,
MACKENZIE N.,
KENNY G. N. C.
Publication year - 1993
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1993.tb06903.x
Subject(s) - propofol , medicine , sedation , anesthesia , blockade , pharmacokinetics , target controlled infusion , blood concentration , surgery , remifentanil , receptor
Summary The ability of a target‐controlled propofol infusion system to provide sedation for 40 patients undergoing surgery under regional blockade was assessed. Eighty‐eight per cent of the total infusion time was at the desired sedation level with little oversedation. This was achieved with a median blood propofol concentration of 0.93 μg.ml −1 . The pharmacokinetic algorithm performed as well when used for sedation as for total intravenous anaesthesia. The predicted and measured blood propofol concentrations showed a bias of—12% and a precision of 34%.