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Propofol and fentanyl act additively for induction of anaesthesia
Author(s) -
BENSHLOMO I.,
FINGER J.,
BARAV E.,
PERL A. Z.,
ETCHIN A.,
TVERSKOY M.
Publication year - 1993
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1993.tb06846.x
Subject(s) - fentanyl , propofol , medicine , anesthesia
Summary The induction dose‐response of propofol was compared with the dose‐response of its combination with fentanyl and with that of fentanyl alone in three groups of 60 women undergoing minor gynaecological surgery. Dose‐response curves were determined for each group using bootstrap and isobolographic analyses. Propofol was found to act additively with fentanyl for induction of anaesthesia. Twenty‐three percent of the ED 50 of fentanyl was required in combination with 75% of the ED 50 for propofol to achieve the ED 50 of the combination. This indicates that, for induction of anaesthesia, propofol and fentanyl are not synergistic.