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Administration of vancomycin during cardiopulmonary bypass
Author(s) -
Baraka A.,
Taha S.,
Bijjani A.,
Arab W.,
Mashefedjian G.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb04213.x
Subject(s) - medicine , cardiopulmonary bypass , anesthesia , vancomycin , extracorporeal circulation , oxygenator , perfusion , hemodynamics , extracorporeal , cardiology , surgery , staphylococcus aureus , biology , bacteria , genetics
Summary Vancomycin was given during cardiopulmonary bypass to 12 anaesthetised patients undergoing open heart surgery. Injection of vancomycin 1 g within 60 s via the venous inlet of the oxygenator resulted in a moderate and transient decrease of mean arterial pressure. This minimal reaction may be attributed to dilution of vancomycin by the extracorporeal circuit volume, to the bypassing of the lungs which are a major site of storage of vasoactive substances, or to the maintenance of adequate perfusion flow during cardiopulmonary bypass. The results suggest that the haemodynamic adverse reactions to vancomycin, given as antibiotic prophylaxis, may be decreased by its administration after initiation of cardiopulmonary bypass.