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Isoflurane and propofol for long‐term sedation in the intensive care unit
Author(s) -
MILLANE T. A.,
BENNETT E. D.,
GROUNDS R. M.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb03254.x
Subject(s) - medicine , sedation , propofol , isoflurane , intensive care unit , anesthesia , intensive care medicine , intensive care , mechanical ventilation , adverse effect , ventilation (architecture) , pharmacology , mechanical engineering , engineering
Summary Propofol and isoflurane have been reported recently to offer better sedation than alternative agents in patients who require long‐term ventilation in the Intensive Care Unit. This is the first report of a direct comparison between propofol and isoflurane. Twenty‐four patients predicted to require artificial ventilation for at least 48 h were entered into a randomised crossover study to monitor sedation quality and time to recovery from sedation. There were no significant differences between the two agents in either end‐point, with over 95% optimal sedation achieved by the use of each drug. Few adverse events were noted. Technological advances in the administration of volatile agents as long‐term sedatives in the Intensive Care Unit may facilitate their more widespread use.