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Catecholamine response to laryngoscopy and intubation
Author(s) -
CHRÆMMERJØRGENSEN B.,
HERTEL S.,
STRØM J.,
HØILUNDCARLSEN P. F.,
BJERREJEPSEN K.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb03252.x
Subject(s) - medicine , laryngoscopy , anesthesia , intubation , fentanyl , catecholamine , hemodynamics , tracheal intubation , midazolam , heart rate , blood pressure , haemodynamic response , mean arterial pressure , sedation
Summary The haemodynamic response and changes in plasma catecholamine concentrations associated with laryngoscopy and tracheal intubation were compared during anaesthesia employing three strictly standardised techniques with commonly used drug combinations. Thirty‐six patients were investigated consecutively resulting in 12 patients in each of three study groups. Anaesthesia was induced with thiopentone 5 mg.kg −1 (group 1), fentanyl 6 ng.kg −1 with thiopentone 5 mg.kg −1 (group 2). or midazolam 0.2 mg.kg −1 with fentanyl 6 ug.kg −1 (group 3). Undesirable changes in haemodynamic effects and an elevation of plasma catecholamine concentrations during laryngoscopy and intubation occurred in group 1. Heart rate and mean arterial pressure increased significantly (34% and 23% respectively). Noradrenaline concentration increased by a maximum of 147%. The addition of fentanyl (groups 2 and 3) attenuated the adverse haemodynamic response and elevation of plasma catecholamine concentrations; heart rate and mean arterial pressure did not differ from pre‐intubation values and plasma catecholamine concentrations decreased steadily. Substitution of thiopentone by midazolam in combination with fentanyl abolished the adverse haemodynamic response and modified the increase in plasma catecholamine concentrations. ‘High‐dose’ opioid anaesthesia is not necessary to produce optimal conditions during laryngoscopy and intubation.