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A comparison of the pharmacodynamics of rocuronium and vecuronium during halothane anaesthesia
Author(s) -
BOOTH M. G.,
MARSH B.,
BRYDEN F. M. M.,
ROBERTSON E. N.,
BAIRD W. L. M.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb03139.x
Subject(s) - rocuronium , medicine , anesthesia , pharmacodynamics , neuromuscular blockade , halothane , vecuronium bromide , bolus (digestion) , rocuronium bromide , neuromuscular blocking agents , pharmacokinetics , propofol , surgery , pharmacology
Summary Thirty healthy patients were randomised to receive either a single bolus dose of rocuronium 0.6mg.kg −1 or vecuronium 0.1 mg.kg −1 during halothane anaesthesia. Onset time, duration 25, duration 75 and train‐of‐four 70 were measured. The onset of neuromuscular blockade following rocuronium was more rapid than vecuronium (p = 0.0001). All other pharmacodynamic parameters were similar. During the first minute following injection of the neuromuscular blocking agent, the heart rate increased by 36% in the rocuronium group but remained stable in those patients who received vecuronium (p = 0.0008). No adverse effects were noted in either group.