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The effect of pre‐induction glycopyrronium on the haemodynamic response of elderly patients to anaesthesia with propofol
Author(s) -
Sneyd J. R.,
Mayall R.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb02341.x
Subject(s) - medicine , propofol , anesthesia , haemodynamic response , hemodynamics , blood pressure , heart rate
Summary This study investigated whether pretreatment with glycopyrronium can attenuate the hypotension caused by anaesthesia of the elderly with propofol. Twenty elderly patients (77.1 ± 2.44 years, mean±SEM) of ASA physical status 2 or 3 scheduled for elective urological procedures were given glycopyrronium 0 (n = 10) or 5 μ.kg −1 (n = 10) in a randomised, double‐blind manner, 5 min before induction of anaesthesia with propofol infused at 600 ml.h −1 (average induction dose 1.7±0.06 mg.kg −1 , mean±SEM) followed by maintenance with a propofol infusion at 10 mg.kg −1 .h −1 . Although glycopyrronium significantly increased heart rate (p < 0.01, AOVA), the decrease in blood pressure 2 and 5 min after induction was similar in both groups. The study had a power of 80% to detect a 20 mmHg difference in systolic arterial pressure between treatment groups with p < 0.05.