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Induction of anaesthesia with propofol using a target‐controlled infusion system
Author(s) -
CHAUDHRI S.,
WHITE M.,
KENNY G. N. C.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb02321.x
Subject(s) - medicine , propofol , anesthesia , target controlled infusion , hemodynamics , temazepam , blood pressure , heart rate , respiratory system , receptor , benzodiazepine , remifentanil
Summary Sixty patients premedicated with temazepam were allocated randomly to receive an infusion of propofol designed to achieve and maintain a target blood concentration of 3, 4 or 5 μg.ml −1 . Induction time was measured from the start of infusion to loss of verbal contact. The success rate of inducing anaesthesia within 3 min of achieving the target concentration was 40% when the predicted target concentration was 3 μg.ml −1 , 75% when the predicted target was 4 μg.ml −1 and 90% when the target was 5 μg.ml −1 . There were no significant differences between the three groups for time to loss of verbal contact in patients who were induced successfully within 3 min. There were significant reductions in arterial pressure 3 min after achieving the target concentrations within the groups but not between them. The frequency of apnoea and pain on injection was small in all groups. Selecting a target concentration of 5 μg.ml −1 would successfully induce anaesthesia in the majority of patients premedicated with temazepam without major haemodynamic or respiratory side effects.