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The absence of teratogenic effects of some analgesics used in anaesthesia
Author(s) -
MARTIN L.V.H.,
JURAND A.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb02267.x
Subject(s) - medicine , pethidine , anesthesia , fentanyl , gestation , teratology , fetus , adverse effect , pregnancy , pharmacology , analgesic , biology , genetics
Summary The possibility exists that agents used in anaesthesia may have adverse teratogenic effects on staff, patients, and developing fetuses. It has been shown that a range of neurotropic drugs, when injected into pregnant mice on the 9th day of gestation, produce a characteristic group of central nervous system malformations in their fetuses. We have studied the possible teratogenicity ofpethidine, fentanyl, phenoperidine and lignocaine when tested in this way and conclude that they appear to have less effect than other neurotropic drugs previously tested.