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Transdermal hyoscine with patient‐controlled analgesia
Author(s) -
SEMPLE P.,
MADEJ T. H.,
WHEATLEY R. G.,
JACKSON I. J. B.,
STEVENS J.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb02220.x
Subject(s) - medicine , anesthesia , nausea , antiemetic , transdermal , vomiting , placebo , postoperative nausea and vomiting , incidence (geometry) , abdominal hysterectomy , surgery , hysterectomy , physics , alternative medicine , pathology , pharmacology , optics
Summary Transdermal hvoscine (Scopoderm TTS CIBA) was compared with placebo in 67 patients receiving postoperative analgesia via a patient‐controlled analgesia system. All patients underwent an abdominal hysterectomy and had a standard anaesthetic. They were followed up in recovery and daily for 3 days postoperatively. Fewer patients in the hyoscine group suffered emetic sequelae in recovery and on the third postoperative day (p < 0.05). The hyoscine group received half the number of supplementary antiemetic doses compared to placebo. However, despite transdermal hyoscine there was still a high (78%) incidence of nausea and vomiting. The only significant (p < 0.05) increase in side effects attributable to hyoscine was a higher reported incidence of visual disturbance on the second day.