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The relationship between the concentration of temazepam in cerebrospinal fluid and sedation in man
Author(s) -
OSBORNE G. A.,
BADCOCK N. R.,
McGRATH P. M.,
RUSSELL W. J.,
FREWIN D. B.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb02169.x
Subject(s) - temazepam , medicine , sedation , cerebrospinal fluid , anesthesia , population , lumbar puncture , receptor , benzodiazepine , environmental health
Summary Twenty‐six patients received oral temazepam and subsequently spinal anaesthesia. Blood and lumbar cerebrospinal fluid temazepam levels were measured together with the degree of sedation. The plasma and cerebrospinal fluid concentrations correlated well with the temazepam dose but even better with the weight standardised dose (r = 0.65, p = 0.0003 and r = 0.75, p = p = 0.00001 respectively). Both the plasma and cerebrospinal fluid concentrations of temazepam were correlated with the patient's sedation (r = 0.42 p = 0.037, and r = 0.46 p = 0.021 respectively), but neither was strong. Thus, although the drug concentration at the receptor may be a major factor in producing sedation, others factors, possibly the receptor population or their responsiveness, are also important contributors.