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Alfentanil increases intracranial pressure when intracranial compliance is low
Author(s) -
MOSS E.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb02011.x
Subject(s) - medicine , intracranial pressure , alfentanil , cerebral perfusion pressure , hydrocephalus , anesthesia , compliance (psychology) , saline , cerebrospinal fluid , cerebrospinal fluid pressure , surgery , cerebral blood flow , fentanyl , psychology , social psychology
Summary Intracranial pressure increases following the administration of alfentanil 1 mg are reported in five patients with suspected normal pressure hydrocephalus who were undergoing infusion of saline into a lateral ventricle to measure cerebrospinal fluid outflow resistance. The increase in intracranial pressure was accompanied by a fall in mean arterial pressure. These observations show that, when the intracranial compliance is reduced, alfentanil can cause considerable increases in intracranial pressure and decreases in cerebral perfusion pressure.

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