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Effects of nicardipine on the circulatory responses to tracheal intubation in normotensive and hypertensive patients
Author(s) -
OMOTE K.,
KIRITA A.,
NAMIKI A.,
IWASAKI H.
Publication year - 1992
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1992.tb01947.x
Subject(s) - nicardipine , medicine , laryngoscopy , anesthesia , blood pressure , intubation , tracheal intubation , heart rate , rate pressure product , circulatory system , saline , cardiology
Summary This study was undertaken to examine the effects of nicardipine on circulatory responses to laryngoscopy and tracheal incubation in normotensive (n = 39) and hypertensive (n = 36) patients. Laryngoscopy and tracheal intubation were performed after induction of anaesthesia with thiamylal, followed by administration of intravenous saline or nicardipine 20 or 30 μg.kg −1 and suxamethonium. Blood pressure and heart rate were recorded, and rate‐pressure product was calculated. Nicardipine 20 and 30 μg.kg −1 prevented the increase in mean arterial pressure after intubation in normotensive and hypertensive patients (p < 0.01 compared with saline). The changes in heart rate after intubation were significantly greater in normotensive patients than in hypertensive patients when 20 or 30 μg.kg −1 of nicardipine was given (p < 0.05 and p < 0.01 respectively). Rate‐pressure product increased significantly (p < 0.01) after intubation in normotensive patients whether nicardipine was administered or not, but the increase was suppressed completely by nicardipine 20 or 30 μg.kg −1 in hypertensive patients. We conclude that nicardipine is effective in preventing the circulatory responses to laryngoscopy and tracheal intubation in hypertensive patients.