Premium
Diamorphine analgesia after Caesarean section
Author(s) -
Smith I. D.,
Klubien K. E.,
Wood M. L. B.,
Macrae D. J.,
Carli F.
Publication year - 1991
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1991.tb09861.x
Subject(s) - medicine , caesarean section , anesthesia , pregnancy , biology , genetics
Summary In a randomised double‐blind study, the efficacy, duration of action and side effects of five diamorphine analgesia regimens following Caesarean section are described. The time to next analgesia was shorter in the 5 mg intramuscular group (3.53 hours) than in any of the four epidural groups: 5 mg (5.7 hours, p = 0.007), 2.5 mg (4.76 hours, p = 0.103), 5 mg with adrenaline 1/200 000 (7.2 hours, p = 0.001) and 2.5 mg with adrenaline 1/200 000 (6.05 hours, p = 0.007). Multiple regression analysis showed that the addition of adrenaline significantly increased the duration of action of epidural diamorphine (p < 0.05). The 5 mg dose with adrenaline showed no advantage when compared with 2.5 mg with adrenaline (p = 0.16). No serious side effects were reported in any group.