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Effect of sufentanil on intracranial pressure in neurosurgical patients
Author(s) -
WEINSTABL C.,
MAYER N.,
RICHLING B.,
CZECH T.,
SPISS C. K.
Publication year - 1991
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1991.tb09596.x
Subject(s) - medicine , cerebral perfusion pressure , intracranial pressure , anesthesia , mean arterial pressure , sufentanil , hemodynamics , intracranial pressure monitoring , blood pressure , perfusion , concomitant , surgery , cardiology , heart rate , cerebral blood flow
Summary The effects of sufentanil on intracranial pressure, mean arterial pressure, cerebral perfusion pressure and heart rate were studied in 20 neurosurgical intensive care unit patients. Epidural intracranial pressure probes were implanted in patients who suffered head injury, intracerebral haemorrhage or underwent tumour resection. Sufentanil was given intravenously in sequential doses of 0.5, 1.0 and 2.0 μg/kg. Fifteen minutes elapsed after each dose. The patients were allocated to either group 1 (baseline intracranial pressure < 20 mmHg) or group 2 (baseline intracranial pressure > 20mmHg). Intracranial pressure did not change significantly in either group. Therefore the falls in mean arterial pressure with the highest dose in both groups and with 1.0 μg/kg in group 2, closely reflect corresponding reductions in cerebral perfusion pressure. As sufentanil in itself exerts no effects on intracranial pressure, concomitant haemodynamic changes are the critical factor for an adequate cerebral perfusion pressure.