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Factors that influence the induction dose of propofol
Author(s) -
McCleane G. J.,
Fogarty D. F.,
Watters C. H.
Publication year - 1991
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1991.tb09320.x
Subject(s) - propofol , medicine , albumin , urea , anesthesia , prospective cohort study , biochemistry , chemistry
Summary Factors that influence the induction of anaesthesia with propofol were investigated in a prospective study of 1000 patients. Pre‐operative albumin and urea concentrations correlated with the minimum induction dose of propofol, but less strong correlations were found with haemoglobin, globulin and total protein concentrations. Age was an important influence on the induction dose of propofol (r = 0.34) which was also closely related to ASA grade. Induction of anaesthesia with propofol is dependant on a number of variables, and this study suggests that pre‐operative albumin and urea concentrations are important.